Floating drug delivery systems are those systems having bulk density less than that of the gastric fluids and remain buoyant for a prolonged period of time in the stomach without being affected by the gastric emptying rate. This work was concerned with the formulation and in-vitro evaluation of effervescent floating tablets of an antibacterial drug. Levofloxacin hemihydrate is considered to be effective for the treatment of H. pylori. The objective of this study was to improve the bioavailability of the drug with reduction in dosing frequency and side effects. The tablets were prepared by using wet granulation method. Six formulations were developed with different concentrations of polymers like xanthan gum and carbopol. FTIR studies showed no evidence on interaction with drug, polymers and excipients. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, in-vitro release, buoyancy lag-time and swelling index. The in-vitro drug release profile showed that formulation (F2) which contains carbopol as polymer exhibited 95.89% drug release at the end of 12 hours. The in-vitro release kinetics reveals that the formulation (F2) follows zero order and the mechanism of drug release was non-fickian.
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